Sphingomyelin synthase 1 mediates hepatocyte pyroptosis to trigger non-alcoholic steatohepatitis

Sphingomyelin synthase 1 mediates hepatocyte pyroptosis to trigger non-alcoholic steatohepatitis

Lipotoxic hepatocyte harm is a major occasion in non-alcoholic steatohepatitis (NASH), however the mechanisms of lipotoxicity should not totally outlined. Sphingolipids and free ldl cholesterol (FC) mediate hepatocyte harm, however their hyperlink in NASH has not been explored. We examined the position of free ldl cholesterol and sphingomyelin synthases (SMSs) that generate sphingomyelin (SM) and …

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