Human intestinal dendritic cell and macrophage subsets in coeliac disease

Human intestinal dendritic cell and macrophage subsets in coeliac disease

Dendritic cells (DC) and macrophages (Mϕ) represent essentially the most plentiful antigen presenting cells in the human intestinal mucosa. In resting circumstances, they’re important to keep up the mechanisms of immune tolerance towards meals antigens and commensals, on the time that they hold the capability to provoke and keep antigen-specific pro-inflammatory immune responses towards invading …

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Gut-derived acetate promotes B10 cells with anti-inflammatory effects

Gut-derived acetate promotes B10 cells with anti-inflammatory effects

Autoimmune ailments are characterised by a breakdown of immune tolerance partly on account of environmental components. The short-chain fatty acid acetate, derived largely from intestine microbial fermentation of dietary fiber, promotes anti-inflammatory regulatory T cells and protects mice from kind 1 diabetes, colitis and allergic reactions. Here, we present that the effects of acetate prolong to a …

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The compelling link between physical activity and the body's defense system.

The compelling link between physical activity and the body’s defense system.

This overview summarizes analysis discoveries inside Four areas of train immunology which have obtained the most consideration from investigators: (1) acute and continual results of train on the immune system, (2) medical advantages of the exercise-immune relationship, (3) vitaminal influences on the immune response to train, and (4) the impact of train on immunosenescence. These scientific discoveries will …

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Rapid Gut Adaptation to Preterm Birth Involves Feeding-Related DNA Methylation Reprogramming of Intestinal Genes in Pigs.

Rapid Gut Adaptation to Preterm Birth Involves Feeding-Related DNA Methylation Reprogramming of Intestinal Genes in Pigs.

Following preterm start, the immature intestine operate and immunology should quickly adapt to deal with bacterial colonization and enteral milk feeding. We hypothesized that intestinal epigenetic modifications are concerned in the intestine response to preterm start and the primary feeding. Using piglets as fashions for infants, preterm, and time period pigs had been fed whole parenteral vitamin (TPN) or …

Rapid Gut Adaptation to Preterm Birth Involves Feeding-Related DNA Methylation Reprogramming of Intestinal Genes in Pigs. Read More »